Dose Heterogeneity in Transarterial Radioembolization after Fractional Administration of Holmium Microspheres: A Study in Perfused Human Tumor-Bearing Liver Explants under MR Imaging

Journal of Vascular and Interventional Radiology 2026 Open access

Read full text
Authors: Anne van den Brekel, Kirsten de Vries, Veerle A. Lantinga, Tess J. Snoeijink, Arja Gerritsen, Milou Boswinkel, Joey Roosen, Alexandra Arranja, Marius Christianus van den Heuvel, Cyril Moers, Jurgen J. Fütterer, Koert Pieter de Jong
+3 more Vincent Erwin de Meijer, Simeon J. S. Ruiter, J. Frank W. Nijsen
DOI: 10.1016/j.jvir.2026.108571
Cited by: 0
References: 32

Abstract

PURPOSE: To investigate dose heterogeneity in liver tumors and nontumor target liver (NTTL) following transarterial radioembolization (TARE) by developing an experimental magnetic resonance (MR) imaging-compatible ex vivo perfusion model based on human tumor-bearing livers and to validate the observed heterogeneity patterns against in vivo data. MATERIALS AND METHODS: Fractionated TARE was performed under MR imaging in 4 machine-perfused human tumor-bearing liver explants using fluorescent holmium microspheres. Dose heterogeneity was quantified by calculating the homogeneity index (HI) from MR imaging-based dose maps (voxel size,

Fields of Study & Subjects

Hepatocellular Carcinoma Treatment and Prognosis Radiopharmaceutical Chemistry and Applications Medical Imaging Techniques and Applications

Publication details

Journal / source
Journal of Vascular and Interventional Radiology
Volume
37
Issue
5
Pages
108571–108571
Publication date
31 January 2026
Language
EN