Kidney Disease: Improving Global Outcomes (KDIGO) life cycle of guideline development series: part 4: translating evidence into KDIGO guideline statements

Kidney International 2026 Open access

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Authors: Laia Oliveras, Amara Sarwal, Benjamin Lazarus, Elie Akl, Chris Carmona, I R Edeki, Jitendra Meena, Joyce Popoola, Robin Vernooij, Gihad Nesrallah, Amy Earley, Reem A. Mustafa
DOI: 10.1016/j.kint.2026.04.032
Cited by: 1
References: 7

Abstract

In this part of the Methods Series, we describe how Kidney Disease: Improving Global Outcomes (KDIGO) guidelines move from evidence synthesis to the development of guideline statements using an adapted Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-to-decision framework. We outline how KDIGO Work Groups consider benefits and harms, certainty of evidence, values and preferences, resource use and costs, and considerations for implementation when determining the direction and strength of recommendations. We also clarify the differences between recommendations and practice points.

Fields of Study & Subjects

Clinical practice guidelines implementation Meta-analysis and systematic reviews Health Policy Implementation Science

Publication details

Journal / source
Kidney International
Publisher
Elsevier BV
Volume
110
Issue
5
Pages
1160-1166
Publication date
1 June 2026
Language
EN