Exercise dose, measurement reliability, and mechanistic inference in fibromyalgia trials: a critical appraisal
Abstract
Fregni et al.1 published a trial examining effects of aerobic vs. non-aerobic exercise combined with tDCS on CPM and clinical outcomes in fibromyalgia. Authors address mechanistic/clinical endpoints within a rigorous framework.1 However, there are interrelated methodological/conceptual concerns that substantially affect the study's internal validity, theoretical coherence, and translational interpretation.
Fields of Study & Subjects
Fibromyalgia and Chronic Fatigue Syndrome Research
Transcranial Magnetic Stimulation Studies
Myofascial pain diagnosis and treatment
Publication details
- Journal / source
- The Lancet Regional Health - Americas
- Volume
- 55
- Pages
- 101384–101384
- Publication date
- 9 February 2026
- Language
- EN