The global HIV metabolome cannot be defined without Africa

The Lancet Regional Health - Africa 2026 Open access

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Authors: Levanco K. Asia, Du Toit Loots, Shayne Mason, Esmé Jansen van Vuren, Lungile Sitole, Fidele Tugizimana, Monray Edward Williams
DOI: 10.1016/j.lanafr.2026.100142
Cited by: 1
References: 7

Abstract

Metabolomics has emerged as an important tool for characterising the metabolic pathways dysregulated by HIV-1 infection and long-term antiretroviral therapy.1 By capturing small molecules that reflect immune activation, chronic inflammation, metabolic dysfunction, and age-related comorbidities among people living with HIV (PLWH),2 metabolomics provides insights into disease biology. As metabolomics increasingly informs biomarker discovery and precision medicine, it is helping define the HIV-1 metabolome, providing a foundation for understanding HIV-1 disease mechanisms, identifying clinically relevant biomarkers, and improving disease monitoring and management.

Fields of Study & Subjects

Metabolomics and Mass Spectrometry Studies HIV-related health complications and treatments HIV Research and Treatment

Publication details

Journal / source
The Lancet Regional Health - Africa
Publisher
Elsevier BV
Pages
100142–100142
Publication date
1 August 2026
Language
EN