Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury versus usual care in primary care: a triple-blind, cluster-randomised controlled trial

The Lancet Primary Care 2026 Open access

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Authors: Ana Mikolić, Penelope M. A. Brasher, Linda C Li, Jeffrey Reynold Brubacher, Frank Xavier Scheuermeyer, Pierre-Paul Lizotte, Wenmei Zou, William J. Panenka, Patrick Michel Archambault, Hazel Park, Kevin Shi, Afshin Khazei
+1 more Noah D. Silverberg
DOI: 10.1016/j.lanprc.2025.100088
Cited by: 0
References: 27

Abstract

Background Clinical practice guidelines for mild traumatic brain injury emphasise proactive management of mental health complications. We evaluated the effectiveness of an automated guideline implementation tool for reducing the risk of mental health disorders after mild traumatic brain injury compared with usual care. Methods We conducted a triple-blind (patient, provider, and assessor), cluster-randomised controlled trial. Adults (age 18–69 years) with recent (

Fields of Study & Subjects

Traumatic Brain Injury Research Clinical practice guidelines implementation Health Policy Implementation Science

Publication details

Journal / source
The Lancet Primary Care
Volume
2
Issue
1
Pages
100088–100088
Publication date
1 January 2026
Language
EN