PLGA/nanofibrillated chitosan-coated titanium nanotube arrays with sequential release capabilities for enhanced antibacterial performance, cell viability, and osteo/angio-genesis

Materials & Design 2026 Open access

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Authors: Hossein Shaygani, Saeed Seifi, Mostafa Jamshidian, Seyed Navid Tavoosi, Behzad Rezaee, Mohamad Shahverdi, Sona Zare, Aisan Peyrovan, Amir Shamloo, Kaivan Mohammadi, Ali Moosavi
DOI: 10.1016/j.matdes.2026.116259
Cited by: 1
References: 97

Abstract

• Titanium nanotube (TNT)-based implant with PLGA and nanofibrillated chitosan coatings were developed. • Sequential release of alendronate and human placenta extract promotes osteogenesis and angiogenesis. • Electrospray deposition and drop casting methods ensure uniform coating and controlled drug release. • Enhanced osteoblast activity, VEGFR-2 expression, and bacterial inhibition zone were observed. • High cell viability, bone marrow stem cell coverage, and improved osteointegration were seen.

Fields of Study & Subjects

Bone Tissue Engineering Materials Graphene and Nanomaterials Applications Orthopedic Infections and Treatments

Publication details

Journal / source
Materials & Design
Publisher
Elsevier BV
Volume
267
Pages
116259–116259
Publication date
24 May 2026
Language
EN