Association of Body Fatness With Hypertension, Dyslipidemia, and Myocardial Infarction in a Multinational Pooled Cohort

Mayo Clinic Proceedings 2026 Open access

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Authors: Vivek Prasad, Chibueze Ogbonnaya, H. Y. Oh, Andrew J. Atkin, Madison M. Kindred, Min‐Jeong Shin, D Y Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan R. Porter, Courtney Kipps
+4 more Jason R. Jaggers, Sui Xu, Carl J. Lavie, Mark Hamer
DOI: 10.1016/j.mayocp.2025.10.014
Cited by: 3
References: 68

Abstract

OBJECTIVE: To investigate the association of dual-energy X-ray absorptiometry-measured body fat percentage (BF%) and trunk fat mass index (TFMI) with hypertension (HTN), dyslipidemia, and myocardial infarction (MI). METHODS: The relationship between body fat parameters and cardiovascular disease (CVD) was studied across individuals in the same body mass index (BMI) group. Data from the UK Biobank, a multicountry large population-based study, and the US and Korean National Health and Nutrition Examination Surveys, generating nationally representative samples, were pooled and harmonized. This cross-sectional analysis included 30,520 women and 27,244 men aged 40 years or older. RESULTS: A significant increase in relative risks (RRs) of HTN across BF% quintiles was seen in men with normal weight, overweight, and obesity (P≤.01) and in normal weight women (P

Fields of Study & Subjects

Body Composition Measurement Techniques Nutrition and Health in Aging Diabetes Cardiovascular Risks and Lipoproteins

Publication details

Journal / source
Mayo Clinic Proceedings
Publisher
Elsevier BV
Volume
101
Issue
2
Pages
270–283
Publication date
6 January 2026
Language
EN