A Landscape Analysis of Human SUMOylation

Molecular & Cellular Proteomics 2026 Open access

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Authors: Shireen S. Al-Momani, Kerry A. Ramsbottom, Andrew Collins, Ellen Boswell, Ivo Alexander Hendriks, Michael L. Nielsen, Alfred C.O. Vertegaal, Ronald T. Hay, Zhi Sun, Yasset Perez Riverol, Emily H. Bowler-Barnett, Maria Jesus Martin
+5 more Jun Fan, Ari Sadanandom, Eric W. Deutsch, Juan Antonio Vizcaíno, Andrew R. Jones
DOI: 10.1016/j.mcpro.2026.101571
Cited by: 1
References: 58

Abstract

SUMOylation is an understudied post-translational modification (PTM) linked to diverse physiological and pathological processes. Advances in enrichment strategies, combined with mass spectrometry (MS), have enabled large-scale mapping of SUMOylation sites. Here, we reanalyzed publicly available MS-based datasets to construct a comprehensive and high-confidence reference set of human SUMOylation sites. Our workflow integrated database searching and scoring through the Trans-Proteomic Pipeline (TPP) with a statistical approach to independently estimate global false localization rate (FLR) of modification sites. SUMOylated lysine sites identified at

Fields of Study & Subjects

Advanced Software Engineering Methodologies Software Engineering Techniques and Practices Ubiquitin and proteasome pathways

Publication details

Journal / source
Molecular & Cellular Proteomics
Publisher
Elsevier BV
Volume
25
Issue
5
Pages
101571–101571
Publication date
20 April 2026
Language
EN