Protocol for the synthesis of N-Alkyl bromomaleimide linkers
Abstract
Herein a straightforward and efficient method for synthesizing bromomaleimides with varied carbon chain lengths to modulate molecular properties has been reported. Compounds 1–4 incorporate a single bromomaleimide unit, while compound 5 features two, enabling dual functionalization. This synthetic approach consistently yields high-purity products in good to excellent yields, with compound 5 offering potential for dual payload conjugation due to its bifunctional structure. The key highlights are: 1. Bromomaleimides offers exceptional stability compared to maleimides counterparts 2. Highly selective for Cysteine modification
Fields of Study & Subjects
Click Chemistry and Applications
Chemical Synthesis and Analysis
Advanced Polymer Synthesis and Characterization
Publication details
- Journal / source
- MethodsX
- Volume
- 16
- Pages
- 103809–103809
- Publication date
- 29 January 2026
- Language
- EN