Antifungal and molecular analysis of gene expression caused by haloperidol in Candida spp.

Microbial Pathogenesis 2026 Open access

Read full text
Authors: Leilson Carvalho de Oliveira, Lara Elloyse Almeida Moreira, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Maria Janielly Castelo Branco Silveira, José Roberto de Oliveira Ferreira, Ana Carolina Medeiros de Oliveira, Bruno Coelho Cavalcânti, Islay Lima Magalhães, José Roberto de Oliveira Ferreira, Manoel Odorico de Moares Filho, João Batista de Andrade Neto
+3 more Lívia Gurgel do Amaral Valente Sá, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva
DOI: 10.1016/j.micpath.2026.108343
Cited by: 3
References: 61

Abstract

homeostasis, followed by mitochondrial membrane depolarization, reduced ATP production, cytochrome c release into the cytosol and metacaspase activation, reduced viability, phosphatidylserine externalization, promoted fragmentation, damage and methylation of DNA. It also induced expression of genes related to oxidative stress. It reduced mitochondrial depolarization and decreased the reduction of glutathione (GSH), causing morphological alterations. The results suggest the apoptotic pathway as the main antifungal mechanism of haloperidol.

Fields of Study & Subjects

Antifungal resistance and susceptibility Fungal Infections and Studies Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
Microbial Pathogenesis
Publisher
Elsevier BV
Volume
213
Pages
108343–108343
Publication date
29 January 2026
Language
EN