Mitochondrial NMNAT3 reduces amyloid aggregates in Drosophila and alters the amyloid processing in the 3xTgAD mouse.
Abstract
eye, APP accumulated in a location- and time-dependent manner, and co-expression of NMNAT3 decreased the total number of aggregates. When expressed in the mouse brain, NMNAT3 did not affect amyloid plaque number or volume; nonetheless, it altered APP processing, leading to the accumulation of oligomers and soluble C-terminal fragments. We conclude that the effects of NMNAT3 on APP differ between models, likely due to differences in access to the sites of protein aggregation and the neuronal environments between flies and mice.
Fields of Study & Subjects
Alzheimer's disease research and treatments
Neuroscience and Neuropharmacology Research
S100 Proteins and Annexins
Publication details
- Journal / source
- PubMed
- Publisher
- Elsevier BV
- Volume
- 4
- Pages
- 1–9
- Publication date
- 1 January 2026
- Language
- EN