Isolated knee septic arthritis revealing disseminated coccidioidomycosis without apparent pulmonary involvement: A case report

Medical Mycology Case Reports 2026 Open access

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Authors: Elias Ledezma Flores, Arturo Urias Pompa, Ariana Betsabet Heredia Pulido, César Noé López Barrón
DOI: 10.1016/j.mmcr.2026.100759
Cited by: 0
References: 23

Abstract

Coccidioidomycosis is an endemic fungal infection that rarely presents as isolated osteoarticular disease in immunocompetent hosts. We report a case of disseminated coccidioidomycosis manifesting as chronic septic arthritis of the tibiofemoral joint without apparent pulmonary involvement in a 32-year-old male. Diagnostic delay and initial immunosuppressive therapy contributed to disease progression. Histopathology confirmed the diagnosis and combined surgical debridement and prolonged antifungal therapy led to favorable outcomes. This case highlights the importance of considering fungal etiologies in chronic monoarthritis in endemic regions.

Fields of Study & Subjects

Fungal Infections and Studies Orthopedic Infections and Treatments Nail Diseases and Treatments

Publication details

Journal / source
Medical Mycology Case Reports
Volume
51
Pages
100759–100759
Publication date
5 January 2026
Language
EN