Collagen depletion, not keloid formation, defines lobomycosis lesions: a paired skin analysis

Medical Mycology Case Reports 2026 Open access

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Authors: Franciely G. Gonçalves, Juliana Mora Veridiano, Nuha Ahmad Dsouki, Maria Aparecida S. Pinhal, Gabriel Z. Laporta
DOI: 10.1016/j.mmcr.2026.100787
Cited by: 1
References: 18

Abstract

. Lesions are often described as keloid-like, but the organization of the dermal extracellular matrix remains poorly characterized. We analyzed paired lesional and non-lesional skin from five patients in the Brazilian Amazon using histology and immunohistochemistry. Picrosirius red staining revealed depletion and disorganization of type I collagen in lesional dermis. Immunohistochemistry showed modest differences in biglycan and decorin expression, with spatial redistribution of biglycan near fungal structures. Patients treated with itraconazole showed lesion stabilization. These findings indicate collagen loss rather than true keloid formation.

Fields of Study & Subjects

Dermatologic Treatments and Research Autoimmune Bullous Skin Diseases Hair Growth and Disorders

Publication details

Journal / source
Medical Mycology Case Reports
Publisher
Elsevier BV
Volume
52
Pages
100787–100787
Publication date
1 April 2026
Language
EN