The expanding roles of adhesion GPCRs in neural circuit assembly
Abstract
Bidirectional trans-synaptic signaling directs synapse formation and neural circuit assembly. Increasing evidence supports that several subfamilies of adhesion G protein-coupled receptors (aGPCRs) control important mechanistic aspects of synapse assembly and neural circuit wiring by combining trans-synaptic adhesion with G protein-coupled receptor signaling. These subfamilies include Latrophilins (ADGRL), CELSRs (cadherin EGF LAG 7-transmembrane receptors/ADGRC), and BAIs (brain angiogenesis inhibitors/ADGRB). Recently, aGPCRs have been linked to neurological disorders, further emphasizing the important roles of these receptors for proper neurological functions. Here, we discuss our current understanding of the functions of several aGPCRs in synaptic circuits and their links to neurological and neurodevelopmental disorders.
Fields of Study & Subjects
Receptor Mechanisms and Signaling
Axon Guidance and Neuronal Signaling
Cellular transport and secretion
Publication details
- Journal / source
- Molecules and Cells
- Publisher
- Elsevier BV
- Volume
- 49
- Issue
- 3
- Pages
- 100328–100328
- Publication date
- 2 February 2026
- Language
- EN