Scaffold hopping strategy toward novel Pyrazolo[3,4-d]pyrimidine-based thiazole frameworks as potential cholinesterase inhibitors for treating Alzheimer’s disease: insight into in vitro and in silico approaches

Journal of Molecular Structure 2026

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Authors: Fakhria A Al-Joufi, Maher S. Alwethaynani, Hina Sarfraz, Faisal Asif, Rafaqat Hussain, Asma Sardar, Yousaf Khan, Fakhrul Hassan, Ammena Y Binsaleh, Nawal Al-Hoshani, Reem Nabil Hassan, Mariam Mojally
DOI: 10.1016/j.molstruc.2026.145424
Cited by: 5
References: 35

Fields of Study & Subjects

Cholinesterase and Neurodegenerative Diseases Enzyme function and inhibition Synthesis and biological activity

Publication details

Journal / source
Journal of Molecular Structure
Publisher
Elsevier BV
Volume
1359
Pages
145424–145424
Publication date
21 January 2026
Language
EN