Synthesis, crystal structure, and bioactivity of two new levosimendan analogues

Enrique Cardenas‐Yong; Jazmin Flores-Monroy; Antonino Arenaza‐Corona; Lucero González-Sebastián; Marcos Flores-Ãlamo; Adrián L. Orjuela; Jorge Alí‐Torres; Benjamín Velasco‐Bejarano; David Morales‐Morales

doi:10.1016/j.molstruc.2026.146656

Synthesis, crystal structure, and bioactivity of two new levosimendan analogues

Journal of Molecular Structure 2026 Open access

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Authors: Enrique Cardenas‐Yong, Jazmin Flores-Monroy, Antonino Arenaza‐Corona, Lucero González-Sebastián, Marcos Flores-Ãlamo, Adrián L. Orjuela, Jorge Alí‐Torres, Benjamín Velasco‐Bejarano, David Morales‐Morales

DOI: 10.1016/j.molstruc.2026.146656

Cited by: 1

References: 45

Abstract

• Two new Levosimendan analogues (compounds II and III) were synthesized via a multistep route involving green methods. • Both compounds were unequivocally characterized including the determination of their single crystal X ray diffraction structures. • Preliminary pharmacological evaluation of the compounds revealed promising cardiovascular effects. • Compound III exhibits positive inotropic and vasodilatory effects, keeping this compound as a promising species for further studies.

Fields of Study & Subjects

HIV/AIDS drug development and treatment Coordination Chemistry and Organometallics Synthesis and Reactivity of Heterocycles

Publication details

Journal / source: Journal of Molecular Structure
Publisher: Elsevier BV
Volume: 1373
Pages: 146656–146656
Publication date: 24 May 2026
Language: EN

References 45