Rational design of FAP-targeted sEVs delivered by microneedles for precision treatment of hypertrophic scars via ferroptosis in hypertrophic scar fibroblasts

Materials Today Bio 2026 Open access

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Authors: Yuekui Xu, Yiqing Zhang, Zijie Sun, Junfeng Gong, Qi Shen, Hao Meng, Xi Liu, Junli Chen, Yaying Hao, Zhan Xu, Kui Ma, Liqian Ma
+4 more Kailu Guo, Xiaohua Pan, Xiaobing Fu, Cuiping Zhang
DOI: 10.1016/j.mtbio.2026.103117
Cited by: 0
References: 46

Abstract

rescue experiments using the ferroptosis inhibitor Ferrostatin-1 confirmed that these effects were specifically mediated by ferroptosis. Collectively, these results support FAP as an actionable targeting handle for preferential delivery to scar fibroblasts and suggest that ferroptosis-associated inactivation of HSFs can be leveraged through a microneedle-enabled, locally retained sEV formulation.

Fields of Study & Subjects

Proteoglycans and glycosaminoglycans research Advancements in Transdermal Drug Delivery Extracellular vesicles in disease

Publication details

Journal / source
Materials Today Bio
Volume
38
Pages
103117–103117
Publication date
13 April 2026
Language
EN