P2-engineered exosomes encapsulating curcumin alleviate cognitive decline in AD-like mice by improving microglia-related neuropathology
Abstract
-Cur significantly suppressed the polarization of BV2 cells toward the M1 phenotype, as well as the secretion of pro-inflammatory cytokines. Finally, we also validated the excellent therapeutic potential of this technology in the 5xFAD mouse model. In conclusion, in this study, we for the first time constructed engineered exosomes that can specifically bind to the NCAM protein on microglia to achieve precise delivery of curcumin by expressing the P2 peptide on their surface, exerting beneficial effects in AD treatment without causing significant adverse effects. This strategy may offer a non-invasive and innovative therapeutic method for the management of brain inflammation-related diseases.
Fields of Study & Subjects
Curcumin's Biomedical Applications
Neuroinflammation and Neurodegeneration Mechanisms
Alzheimer's disease research and treatments
Publication details
- Journal / source
- Materials Today Bio
- Publisher
- Elsevier BV
- Volume
- 39
- Pages
- 103388–103388
- Publication date
- 24 June 2026
- Language
- EN