Neuronal VIP wires the intestinal epithelial cell function

Mucosal Immunology 2026 Open access

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Authors: Ziad Al Nabhani, Valentin Thevin, Luisa Morelli
DOI: 10.1016/j.mucimm.2026.01.006
Cited by: 4
References: 9

Abstract

Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type 2 immunity, and establishes a neuro-epithelial circuit preserving gut barrier integrity.

Fields of Study & Subjects

Neuropeptides and Animal Physiology Renin-Angiotensin System Studies Protein Hydrolysis and Bioactive Peptides

Publication details

Journal / source
Mucosal Immunology
Publisher
Elsevier BV
Volume
19
Issue
1
Pages
1679–1681
Publication date
20 January 2026
Language
EN