Inhaled Acinetobacter lwoffii exposure promotes lung PD-L1+ neutrophils and dampens viral-induced type 2 immunity

Mucosal Immunology 2026 Open access

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Authors: Kunyuan Tian, Lucía Labeur-Iurman, Simone A. Walker, Dimple Zope, Erika von Mutius, James A. Harker, Clare M. Lloyd, Sejal Saglani
DOI: 10.1016/j.mucimm.2026.02.007
Cited by: 0
References: 48

Abstract

Wheeze is a common childhood respiratory symptom triggered by seasonal viral infections. Approximately 30–50% of children are diagnosed with at least one wheezing episode in the first three years of life.1 Wheezing disorders resolve in most children, but approximately 30% of children under 5 years continue to have recurrent wheezing episodes triggered by viral infections and an increased risk of developing asthma in childhood.2,3

Fields of Study & Subjects

Asthma and respiratory diseases IL-33 ST2 and ILC Pathways interferon and immune responses

Publication details

Journal / source
Mucosal Immunology
Volume
19
Issue
3
Pages
100326–100326
Publication date
27 February 2026
Language
EN