Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature

Journal de Mycologie Médicale 2026 Open access

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Authors: Pauline Kapustin, Aline Munting, Benoît Desgraz, Etienne Ménager, Jérémy Brühlmann, Jocelyn CORBAZ, Truong‐Thanh Pham, Sylvain Meylan, Daniel Wagner, Yves Harder, Frederic LAMOTH
DOI: 10.1016/j.mycmed.2026.101610
Cited by: 2
References: 29

Abstract

Soft tissue mucormycosis is a rare fungal infection that can develop on contaminated wounds. We report a case of Mucor circinelloides ankle infection in an immunocompetent man following a high-energy motorcycle accident, which has successfully been treated by surgery (multiple debridements, arthrodesis, soft tissue defect reconstruction with flap and skin graft), systemic antifungal therapy (initial liposomal amphotericin B followed by isavuconazole) and hyperbaric oxygen. This case highlights the therapeutic challenges and need for a multidisciplinary approach of such infection.

Fields of Study & Subjects

Antifungal resistance and susceptibility Fungal Infections and Studies Nail Diseases and Treatments

Publication details

Journal / source
Journal de Mycologie Médicale
Publisher
Elsevier BV
Volume
36
Issue
1
Pages
101610–101610
Publication date
4 February 2026
Language
EN