THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression

Neoplasia 2026 Open access

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Authors: Shreya Budhiraja, Umme H Faisal, Shivani Baisiwala, Rafał Chojak, Lara Koutah, Noah B. Drewes, Sia Cho, Hasaan A Kazi, Rebecca Chen, Ella N. Perrault, Li Chen, Cheol H. Park
+7 more Maeve C. O’Shea, Khizar Rehan Nandoliya, Joseph T. Duffy, Peiyu Lin, Adam M. Sonabend, Crismita Dmello, A. Karim Ahmed
DOI: 10.1016/j.neo.2025.101271
Cited by: 0
References: 56

Abstract

Glioblastoma (GBM), the most common and aggressive primary malignant brain tumor in adults, has a median survival of 14.6 months. To identify drivers of GBM pathogenesis, we conducted a CRISPR-knockout screen, which revealed THO Complex 1 (THOC1) as a key driver. Knocking down THOC1 significantly reduced GBM cell viability across patient-derived xenograft (PDX) lines, enhancing survival (p

Fields of Study & Subjects

DNA Repair Mechanisms Glioma Diagnosis and Treatment Epigenetics and DNA Methylation

Publication details

Journal / source
Neoplasia
Volume
72
Pages
101271–101271
Publication date
6 January 2026
Language
EN