Molecular connectivity studies of cerebral glucose metabolism and blood flow: A scoping review

Neuroscience & Biobehavioral Reviews 2026 Open access

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Authors: Carlo Cavaliere, Alice Galli, Chiara Meneghini, Mario Severino, Débora Elisa Peretti, Martin Nørgaard, Chunmeng Tang, Anna Lisa Martini, Marjorie Bardiau, Matthieu Doyen, Gabriel Gonzalez-Escamilla, Tatiana Horwitz
+17 more Matej Perovnik, Michael Rullmann, Daniel Talmasov, Tommaso Volpi, Zhilei Xu, Vince Calhoun, Xin Di, Simon B. Eickhoff, Christian Habeck, Sharna Jamadar, Daniela Perani, Vesna Sossi, Igor Yu. Yakushev, Arianna Sala, Joana B. Pereira, Mattia Veronese, Silvia Paola Caminiti
DOI: 10.1016/j.neubiorev.2026.106623
Cited by: 3
References: 377

Abstract

F]FDG-PET at rest, emerged as robust marker of functional integrity and disease progression, especially in neurodegenerative conditions. Multimodal PET/MRI studies revealed partial overlap between metabolic and hemodynamic connectivity. Noteworthy findings include the identification of default mode network through the study of CBF and disease-related covariance patterns in neurodegenerative disorders through the study of glucose metabolism. Integrating macroscale molecular brain organization studies with neurophysiological techniques will deepen the understanding of brain connectivity in health and disease. Additionally, total-body PET/MRI data may in the future elucidate brain-body interactions fostering a more comprehensive connectome framework.

Fields of Study & Subjects

Bioinformatics and Genomic Networks Neurological Disease Mechanisms and Treatments Barrier Structure and Function Studies

Publication details

Journal / source
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Volume
185
Pages
106623–106623
Publication date
5 March 2026
Language
EN