Cryo-EM structure enabling virtual screening for the discovery of highly potent TRPM3 antagonists with analgesic efficacy

Neuron 2026 Open access

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Authors: Tingting Yang, Tong Che, Hongmin Guo, Xinyu Cheng, Mingyang Wang, Sijia Lv, Xiaoqiang Yang, Xiaoyun Wu, Yinzhen Liu, Hui Liu, Han Jun Hu, Wenlu Li
+13 more Shuangyan Wan, Haoxiang Peng, Weiwei Nan, Yuting Zhang, Bo Zeng, Erwin Neher, Ougen Liu, Bo Yu, Fengxian Li, Guilin Li, Jian Li, Jingjing Duan, Jin Zhang
DOI: 10.1016/j.neuron.2025.12.045
Cited by: 1
References: 90

Fields of Study & Subjects

Ion Channels and Receptors Calcium signaling and nucleotide metabolism Magnesium in Health and Disease

Publication details

Journal / source
Neuron
Publisher
Elsevier BV
Volume
114
Issue
9
Pages
1609–1622.e6
Publication date
24 February 2026
Language
EN