Neuroprotective therapy after traumatic brain injury: does the window for treatment extend for months?
Abstract
Over 2% of US residents live with traumatic brain injury (TBI) related disability [1], and TBI is recognized as a risk factor for neurodegenerative dementia in late life [2]. Post-mortem histopathological examination of human brain tissues from patients dying in both the acute and chronic phases following TBI point toward a combination of neuropathological processes initiated by brain trauma but persisting for months and years that underlie these chronic neurological deficits [3]. Almost all research attempting to develop neuroprotective therapies for TBI, both in experimental models and humans, has focused on the acute period after injury [4], on the assumption that the window of opportunity to prevent secondary injury is in the order of hours, or at most a few days.
Fields of Study & Subjects
Traumatic Brain Injury and Neurovascular Disturbances
Traumatic Brain Injury Research
Neurological Disorders and Treatments
Publication details
- Journal / source
- Neurotherapeutics
- Publisher
- Elsevier BV
- Volume
- 23
- Issue
- 3
- Pages
- e00908–e00908
- Publication date
- 1 April 2026
- Language
- EN