"When is it late"? Optimal threshold for duration of untreated illness (DUI) to predict SSRI-treatment resistance in obsessive-compulsive disorder (OCD)

Conclusion: This study reveals a significant correlation between previous psychological trauma and the incidence of self-harm behaviour among COVID-19 patients during isolation.Patients with a history of previous psychological trauma are four times more at risk of self-harming behaviour.The finding underscores the heightened risk faced by individuals with trauma histories, who may experience exacerbated mental health challenges in the context of enforced solitude and stress.Exacerbation of loneliness during isolation was associated with an increase in the odds of self-harm.Loneliness and self-harm behaviour were closely linked [1].The enhanced stress perception may serve as a key pathway for the continuation and development of self-harm behaviour among a vulnerable population facing adverse life events.Future research should focus on the neurobiological mechanisms linking isolation and trauma to self-harm behaviour and examine the effectiveness of various pharmacological and psychological treatments in this unique circumstance.References 1. Geulayov,