Cardiac [18F]fluoroethoxybenzovesamicol uptake is not specific to vesicular acetylcholine transporter in mice and pigs

Journal of Nuclear Cardiology 2026 Open access

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Authors: Emily L. Hoddinott, Uzair S. Ismailani, Ariel Buchler, Faduma Abdirahman, Kate M. Onuska, Gedaliah Farber, Zacharie Saint-Georges, Taylor W. Schmitz, Lauri J. Tuominen, Benjamin H. Rotstein
DOI: 10.1016/j.nuclcard.2026.102733
Cited by: 1
References: 4

Abstract

Cardiac positron emission tomography (PET) imaging of the parasympathetic nervous system (PNS) has proven to be difficult due to the low density of parasympathetic neurons in the ventricles and the challenges associated with quantifying the anatomically smaller and thinner, though densely innervated, atrial wall. Rodent and human cardiomyocytes independently express choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT), and acetylcholine esterase (AChE) [1]. Given the emerging role of aberrant cholinergic signaling in the progressive worsening of cardiac function, molecular imaging could play a role in detecting biochemical dysfunction at the onset of disease [2].

Fields of Study & Subjects

Viral Infections and Immunology Research Cardiac electrophysiology and arrhythmias Cardiac Arrhythmias and Treatments

Publication details

Journal / source
Journal of Nuclear Cardiology
Publisher
Elsevier BV
Volume
62
Pages
102733–102733
Publication date
17 April 2026
Language
EN