The chemo-biochemical convergence in nanomedicine: A review of tailored therapeutic strategies

This review examines the emerging concept of "chemo-biochemical convergence" within the field of nanomedicine, which represents a synergistic integration of synthetic chemistry and biological principles aimed at developing advanced therapeutic systems. The primary objective is to investigate how the meticulous chemical engineering of nanoplatformsestablishes a robust foundation for complex biological functionality. Key findings from this domain indicate that this approach facilitates both passive targeting via the Enhanced Permeability and Retention effect and active targeting through the use of surface-conjugated ligands. Additionally, it supports the creation of "smart" systems that enable on-demand drug release in response to distinct microenvironmental stimuli such as pH, redox potential, and temperature. This is exemplified by the clinical application of Doxorubicin (DOX) nanocarriers, which demonstrate improved efficacy and diminished systemic toxicity. The potential for future integration with artificial intelligence and synthetic biology suggests transformative opportunities for the development of highly personalized, adaptive, and effective treatments.