Single-cell transcriptomics of multi-site cell therapy in osteoarthritis: Tissue-specific treatment correlations

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Paramita Chatterjee, Hazel Y Stevens, Linda Kippner, Carolyn Yeago, Hicham Drissi, Kenneth Mautner, Scott D. Boden, Greg Gibson, Krishnendu Roy
DOI: 10.1016/j.omtn.2026.102839
Cited by: 2
References: 46

Abstract

) signaling. Cell-cell communication analysis suggested enhanced human leukocyte antigen (HLA) signaling in non-responder MSCs (mesenchymal stromal cells), consistgenesent with inflammation, while responders showed more coordinated immune interactions. BMAC-MSCs promoted chondrocyte proliferation, whereas SVF-MSCs emphasized immune regulation. This study suggests that variability in therapy outcomes reflects patient heterogeneity beyond genomic factors, complicating the immediate use of genomic profiling to guide treatment. Nonetheless, as molecular pathways become better understood, integrating genomic insights into personalized strategies may become feasible.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Mesenchymal stem cell research Immune cells in cancer

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
1
Pages
102839–102839
Publication date
20 January 2026
Language
EN