Oral ginger-derived extracellular vesicles ameliorate arthritis via anti-inflammatory actions of microRNA-149 and 6-gingerol

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Hiroki Kaneta, Tomoyuki Nakasa, Dilimulati Yimiti, Dan Moriwaki, Riku Kawasaki, Toshihiko Ogura, Shigeru Miyaki, Nobuo Adachi
DOI: 10.1016/j.omtn.2026.102840
Cited by: 5
References: 77

Abstract

, oral administration of GDEVs to CAIA mice reduced arthritis severity, attenuated synovitis, preserved cartilage integrity, and suppressed osteoclast activation. GDEVs were stable against gastric digestion and were efficiently taken up by intestinal cells, supporting their oral availability. Microarray and RNA sequencing identified miR-149 as a key regulatory molecule in GDEVs, associated with the suppression of inflammation-related signaling pathways, including Ras signaling and mitogen-activated protein kinase (MAPK) cascades. These findings highlight the potential of GDEVs as an anti-inflammatory therapy for RA. Given their stability and bioavailability, the oral administration of GDEVs could be a promising non-invasive treatment for future clinical applications.

Fields of Study & Subjects

Extracellular vesicles in disease Immune cells in cancer Rheumatoid Arthritis Research and Therapies

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
1
Pages
102840–102840
Publication date
20 January 2026
Language
EN