Lipid self-assembling nanoparticles as a novel platform for mRNA-based vaccination

Molecular Therapy — Nucleic Acids 2026 Open access

Read full text
Authors: Arianna De Chiara, Valeria Nele, Alessia Angelillo, Virginia Campani, Andrea Campanile, Guendalina Froechlich, Annagiulia Scognamiglio, Emilio Pellino, Antonietta Greco, Clizia Chinello, Lisa Pagani, Remo Eugster
+5 more Paola Luciani, Claudia Corbo, Alfredo Nicosia, Emanuele Sasso, Giuseppe De Rosa
DOI: 10.1016/j.omtn.2026.102851
Cited by: 1
References: 43

Abstract

biodistribution. Finally, mRNA-SANPs encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein elicited a significant immune response in mice following both IM and IV administration.

Fields of Study & Subjects

RNA Interference and Gene Delivery Immunotherapy and Immune Responses Nanoparticle-Based Drug Delivery

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
1
Pages
102851–102851
Publication date
31 January 2026
Language
EN