Cytolysis limits IFN-I and effector memory CD8 T cells after viral vector vaccination
Abstract
Viral vectors are powerful tools in vaccine development, particularly because of their ability to induce robust CD8 T cell responses. However, how vector replicative capacity and cytolytic activity shape CD8 T cell responses remain incompletely understood. In this issue of Molecular Therapy Nucleic Acids, Ciancaglini et al. demonstrate that converting a cytolytic vesicular stomatitis virus (rVSV) vaccine vector into a non-cytolytic form (rVSVMq) enhances effector memory CD8 T cell responses and improves protection against infection.
Fields of Study & Subjects
Virus-based gene therapy research
Immunotherapy and Immune Responses
HIV Research and Treatment
Publication details
- Journal / source
- Molecular Therapy — Nucleic Acids
- Volume
- 37
- Issue
- 2
- Pages
- 102885–102885
- Publication date
- 15 March 2026
- Language
- EN