Aging alters synergistic microRNA networks in exosomes to stimulate repair in lung injury and skin wound healing

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Sharon J. Elliot, Sam Grimaldo, Paola Catanuto, Simone Pereira-Simon, Xiaomei Xia, Gina Civettini, Shahriar Shahzeidi, Irena Pastar, Marjana Tomic-Canic, Marilyn K. Glassberg
DOI: 10.1016/j.omtn.2026.102927
Cited by: 1
References: 81

Abstract

experiments confirmed alterations in multiple downstream pathways, mediating reparative effects. These findings underscore age-dependent differences in stem cell-derived exosomes and demonstrate that synergistic miRNA cargo drives maximal efficacy.

Fields of Study & Subjects

Extracellular vesicles in disease MicroRNA in disease regulation Planarian Biology and Electrostimulation

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
2
Pages
102927–102927
Publication date
3 April 2026
Language
EN