Directed evolution of novel AAV capsids for enhanced delivery to mouse and human Schwann cells

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: A. Carneiro, Alan M. Nisanov, HyunCheol Lee, David V. Schaffer
DOI: 10.1016/j.omtn.2026.102928
Cited by: 3
References: 36

Abstract

studies of mouse-tropic capsids confirmed higher selectivity, improved packaging titers, and decreased localization to the liver. These engineered AAVs are valuable tools for studying Schwann cells and offer new avenues for the treatment of peripheral nerve disorders.

Fields of Study & Subjects

Nerve injury and regeneration Virus-based gene therapy research Facial Nerve Paralysis Treatment and Research

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
2
Pages
102928–102928
Publication date
3 April 2026
Language
EN