Dual inhibition of intercellular adhesion molecule-1 and nucleolin reduces RSV infection efficiency in human respiratory organoids

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Abeer Keshta, Rina Hashimoto, Yuki Kitai, Yoshitaka Nakata, Ayaka Sakamoto, Shimpei Gotoh, Makoto Takeda, Kazuo Takayama
DOI: 10.1016/j.omtn.2026.102932
Cited by: 1
References: 27

Abstract

nucleoprotein gene expression, whereas inhibition of EGFR or IGF1R had no observable effect on viral gene expression. Notably, simultaneous suppression of ICAM-1 and NCL resulted in a more substantial reduction in infectious viral titers and RSV F protein expression than inhibition of either protein alone. Our results suggest that both ICAM-1 and NCL may play important roles during RSV infection in human iPSC-derived respiratory organoids.

Fields of Study & Subjects

Respiratory viral infections research interferon and immune responses Viral Infections and Immunology Research

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
2
Pages
102932–102932
Publication date
17 April 2026
Language
EN