Multiscale modeling guided potency assessment of mRNA-lipid nanoparticles

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Yuling Yang, Yuchen Qiu, Keqi Wang, Yifang Liu, Gautam Sanyal, Paul C. Whitford, Sara H. Rouhanifard, Wei Xie
DOI: 10.1016/j.omtn.2026.102965
Cited by: 1
References: 86

Abstract

hybridization (smFISH) for single-cell resolution of mRNA and protein expression, our framework provides mechanistically grounded modeling and robust prediction of therapeutic potency, offering a powerful platform for optimizing mRNA-based interventions.

Fields of Study & Subjects

Lipid Membrane Structure and Behavior RNA Interference and Gene Delivery Nanoparticle-Based Drug Delivery

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
2
Pages
102965–102965
Publication date
26 May 2026
Language
EN