CD39 mRNA therapy attenuates localized acute inflammation: A novel anti-inflammatory strategy using cationic nanoliposomes

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Naomi R. Philosof, Aidan P. G. Walsh, Bangyan Xu, Anna M.D. Watson, Shulei Ren, Ludmilla Hann, Benedict Nathaniel, Anne Nguyen, Haikun Liu, Pu Shi, Viktoria Bongcaron, Hung Nguyen
+5 more Jonathan Noonan, Meltem Avci‐Adali, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang
DOI: 10.1016/j.omtn.2026.102966
Cited by: 1
References: 60

Abstract

in treated mice, with liver enzymes and histological analysis supporting formulation's safety and favorable tolerability. These findings establish CD39 mRNA-NLps as a safe, effective strategy for a spatially confined mRNA-based approach to regulate local inflammation.

Fields of Study & Subjects

Adenosine and Purinergic Signaling RNA Interference and Gene Delivery Pediatric health and respiratory diseases

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
2
Pages
102966–102966
Publication date
25 May 2026
Language
EN