Systemically delivered mRNA-LNPs transfect primary and secondary liver tumors

Molecular Therapy — Nucleic Acids 2026 Open access

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Authors: Laura J. Leighton, Yee Jing Gee, Sachithrani U. Madugalle, Maria Victorova, Nissa L. Carrodus, Kim R. Bridle, Sidney A. Howell, Xiaowen Liang, Gregory C. Miller, Chris L.D. McMillan, Danushka K. Wijesundara, David A. Muller
+3 more Dorothy H. Crawford, Tim R. Mercer, Seth W. Cheetham
DOI: 10.1016/j.omtn.2026.102989
Cited by: 1
References: 67

Abstract

. Delivery of mRNA is also possible in xenograft models of both primary and secondary liver cancer, albeit with attenuated protein expression relative to the normal liver. These findings demonstrate the potential for systemically delivered mRNA-LNP therapies for liver disease and cancer.

Fields of Study & Subjects

RNA Interference and Gene Delivery RNA Research and Splicing RNA regulation and disease

Publication details

Journal / source
Molecular Therapy — Nucleic Acids
Publisher
Elsevier BV
Volume
37
Issue
3
Pages
102989–102989
Publication date
17 June 2026
Language
EN