Survivin/BIRC5-derived peptide disrupts survivin dimerization and cell division and induces multifaceted anti-cancer effects

Molecular Therapy Oncology 2026 Open access

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Authors: Manikandan Santhanam, Venkatadri Babu, Anna Shteinfer-Kuzmine, Swaroop Kumar Pandey, Larisa Gheber, Gilead Raday, Varda Shoshan-Barmatz
DOI: 10.1016/j.omton.2025.201123
Cited by: 2
References: 139

Abstract

models. These findings highlight a novel strategy for targeting undruggable survivin using survivin-derived engineered peptides, offering promising therapeutic potential in cancer.

Fields of Study & Subjects

Cell death mechanisms and regulation Phagocytosis and Immune Regulation Cancer Immunotherapy and Biomarkers

Publication details

Journal / source
Molecular Therapy Oncology
Publisher
Elsevier BV
Volume
34
Issue
1
Pages
201123–201123
Publication date
3 January 2026
Language
EN