Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells

Molecular Therapy Oncology 2026 Open access

Read full text
Authors: Juliane Mietz, Lukas Egli, Meike Misiune, Arianna Picozzi, Nicolò Coianiz, Danielle Thompson, Marianna Ponzo, Alisson Charmey, Beat Bornhäuser, Chiara F. Magnani, Christian Münz, Obinna Chijioke
DOI: 10.1016/j.omton.2026.201126
Cited by: 3
References: 55

Abstract

. Together, our findings present a novel approach to enhance both cytotoxicity and persistence of CAR NK cell in cancer immunotherapy and reduce the risk of antigen-negative relapse.

Fields of Study & Subjects

Immune Cell Function and Interaction CAR-T cell therapy research Immunotherapy and Immune Responses

Publication details

Journal / source
Molecular Therapy Oncology
Publisher
Elsevier BV
Volume
34
Issue
1
Pages
201126–201126
Publication date
9 January 2026
Language
EN