Beyond autologous ex vivo CAR-expressing cell therapies: Toward allogeneic and nucleated cell-free delivery systems of CAR

Molecular Therapy Oncology 2026 Open access

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Authors: Kathrine S Rallis, Laura M. Dionisio, Mubin Tarannum, Rizwan Romee, José A. Cancelas
DOI: 10.1016/j.omton.2026.201155
Cited by: 1
References: 104

Abstract

engineering. Despite this promise, challenges remain, including cell-specific targeting, control of transgene persistence, immunogenicity, and regulatory considerations. Together, these innovations signal a paradigm shift in the generation and deployment of CAR-based cellular immunotherapies.

Fields of Study & Subjects

CAR-T cell therapy research Virus-based gene therapy research RNA Interference and Gene Delivery

Publication details

Journal / source
Molecular Therapy Oncology
Publisher
Elsevier BV
Volume
34
Issue
1
Pages
201155–201155
Publication date
13 February 2026
Language
EN