Synthetic biology integrated with material science paves the way for next-generation smart cell therapies
Abstract
Pulmonary metastasis represents a major bottleneck in cancer survival, responsible for nearly one-third of solid tumor deaths.1 The eradication of these lesions is hindered by the lung’s complex vascular architecture,2 which restricts drug access, and the insidious nature of micrometastases, which evade surgical clearance. Current systemic therapies thus face a steep therapeutic index, where the dose required to penetrate the alveolar barrier inevitably triggers severe off-target toxicity.
Fields of Study & Subjects
CAR-T cell therapy research
Tissue Engineering and Regenerative Medicine
Bacterial Cancer Therapy
Publication details
- Journal / source
- Molecular Therapy Oncology
- Volume
- 34
- Issue
- 1
- Pages
- 201157–201157
- Publication date
- 1 March 2026
- Language
- EN