Engineered indoleamine 2,3-dioxygenase variant: Oxidative activation of prodrug indole-3-acetic acid against cancer cells for targeted therapy

Molecular Therapy Oncology 2026 Open access

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Authors: Liru Liu, Wanfang Li, Sheng Ye

DOI: 10.1016/j.omton.2026.201310

Cited by: 1

References: 66

Abstract

-IAA pair as an efficient enzyme-prodrug combination, representing a promising therapeutic modality for enzyme-activated prodrug therapy in oncology.

Tryptophan and brain disorders Epigenetics and DNA Methylation Genomics phytochemicals and oxidative stress

References 66