Endothelial Cell Therapy for Postkeratoplasty Corneal Endothelial Failure

Ophthalmology 2026 Open access

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Authors: Yuto Kataoka, Morio Ueno, Takefumi Yamaguchi, Yasufumi Tomioka, Koichi Wakimasu, Mariko Shirane, Koji Kitazawa, Hideki Fukuoka, Tsutomu Inatomi, Chie Sotozono, Shigeru Kinoshita
DOI: 10.1016/j.ophtha.2026.08.007
Cited by: 1
References: 7

Abstract

Corneal transplantation, including penetrating keratoplasty (PKP), Descemet stripping automated endothelial keratoplasty (DSAEK), and Descemet membrane endothelial keratoplasty (DMEK), is a well-established and highly effective surgical treatment for corneal blindness. However, chronic endothelial cell dysfunction and/or allogeneic immunologic rejection may necessitate repeat keratoplasty. In addition to increased surgical complexity, repeat keratoplasty is associated with a higher incidence of postoperative complications, including immunologic reaction and secondary glaucoma.

Fields of Study & Subjects

Corneal Surgery and Treatments Corneal surgery and disorders Ocular Surface and Contact Lens

Publication details

Journal / source
Ophthalmology
Publisher
Elsevier BV
Volume
133
Issue
11
Pages
1395-1398
Publication date
1 August 2026
Language
EN