Prognostic and recurrence implications of subdividing WHO grade 2 pancreatic neuroendocrine tumors at a 10% Ki-67 threshold

Pancreatology 2026 Open access

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Authors: Go-Won Choi, Inhyuck Lee, Younsoo Seo, Youngmin Han, Yoon Soo Chae, Hye-Sol Jung, Young Jae Cho, Wooil Kwon, Jin-Young Jang, Joon Seong Park
DOI: 10.1016/j.pan.2026.01.079
Cited by: 2
References: 19

Abstract

BACKGROUND: Although World Health Organization (WHO) grade 1 and 2 pancreatic neuroendocrine tumors (pNETs) are generally regarded as indolent, substantial biological heterogeneity exists, particularly within grade 2 (G2) tumors. This study evaluated whether subdividing G2 pNETs using new Ki-67 threshold improves postoperative risk stratification following curative resection. METHODS: We retrospectively analyzed consecutive adults who underwent pancreatectomy for pNETs between 2010 and 2022. Tumors were classified as G1 (

Fields of Study & Subjects

Neuroendocrine Tumor Research Advances Pancreatic and Hepatic Oncology Research Lung Cancer Research Studies

Publication details

Journal / source
Pancreatology
Publisher
Elsevier BV
Volume
26
Issue
2
Pages
265–271
Publication date
3 February 2026
Language
EN