New C22-related terpenoid from Formosan marine sponge Lendenfeldia sp.

A new C₂₂ furanoterpenoid, lendenfurone A ( 1 ), was isolated from the Formosan marine sponge Lendenfeldia sp. C₂₂ furanoterpenoids are rare among sponge-derived natural products, with only two compounds (furodendin and dehydrofurodendin) reported to date. The structure of 1 was elucidated by NMR spectroscopy and HRESIMS, and the absolute configuration was established by specific optical rotation (SOR) prediction and confirmed through DFT-based NMR calculations with DP4⁺ analysis. Although compound 1 showed no significant anti-osteoclastogenic activity in PMA/RANKL-induced THP-1 cells, it exhibited no cytotoxicity. The unique scaffold of lendenfurone A may serve as a promising lead for future pharmacological studies. • A new C₂₂ furanoterpenoid, lendenfurone A, was isolated from Lendenfeldia sp. • Structure elucidation was confirmed by NMR, HRESIMS, and DP4⁺ analysis. • Lendenfurone A has a unique scaffold and shows no cytotoxicity or bioactivity.