Two new compounds isolated from a sponge-derived fungus Diaporthe sp. ZYX-Z-582

Two new compounds, 1-chloro-decarboxyunguinolic acid ( 1 ) and 6-hydroxy-3-methyloctan-4-yl-2,4-dihydroxy-6-methylbenzoate ( 2 ), along with seven known ones ( 3 - 9 ), were isolated from a sponge-derived fungus Diaporthe sp. ZYX-Z-582. Five compounds ( 1–5 ) exhibited inhibitory activity against agricultural pathogenic fungi Neoscytalidium dimidiatum ZYXPF03, Gilbertella persicaria HLG-T, Fusarium oxysporum f. sp. Passiflorae ZYXPF10 and Colletotrichum musae ZYXPF01, with MIC values ranging from 8 μg/mL to 128 μg/mL. • Chemical investigation on the fungus Diaporthe sp. ZYX-Z-582 was performed. • Two new compounds (1 and 2) were isolated and identified from this fungus. • Compounds 1 and 4 showed broad-spectrum antifungal activity against all four tested agricultural pathogens.