Fusariacumines A C, indole alkaloids from Fusarium acuminatum J207-2 with antibacterial activity
Abstract
In order to search for antibacterial agents against kiwi plant pathogen Pseudomonas syringae pv. actinidiae (Psa), a Gram-negative bacterium that causes kiwi bacterial canker, three new indole alkaloids, fusariacumines A–C ( 1 – 3 ), together with two known ones ( 5 and 6 ) have been isolated from a kiwi plant-associated fungus Fusarium acuminatum J207–2. Their chemical structures were determined by spectroscopic methods (1D, 2D NMR and HRESIMS). Compounds 1 and 3–5 exhibited moderate anti-Psa activity with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/mL.
Fields of Study & Subjects
Microbial Natural Products and Biosynthesis
Synthesis and bioactivity of alkaloids
Plant Pathogens and Fungal Diseases
Publication details
- Journal / source
- Phytochemistry Letters
- Volume
- 72
- Pages
- 104120–104120
- Publication date
- 19 January 2026
- Language
- EN