Cerebral hemodynamic changes and their effects on cognitive function in patients with Parkinson's disease complicated with orthostatic hypotension

Objective: This article explores the relationship between OH and cerebral hemodynamics in PD patients, and clarifies the correlation between OH and cognitive function in PD patients. Methods: The included PD cases were divided into OH positive and OH negative groups according to Active standing test (AST). In the supine position test, cerebral blood flow velocity (CBFv) and pulsitility index (PI) were continuously monitored by TCD, and blood pressure and heart rate in the supine position and standing position for 1st, 3rd and 5th minute were recorded. Results: In the chi-square test, 87.5% of patients with Parkinson's disease with orthostatic hypotension (PD-OH) had poor W spike correction, while only 12.2% of patients in Parkinson's disease with non-orthostatic hypotension (PD-NOH) group had OH symptoms,and 14.6% of patients had poor W spike correction. MoCA scores and Mild Cognitive Impairment (MCI) were significantly higher in OH with poor W spike callback than in W spike disappearance group and normal response groups (P