Combined effects of incubation temperature and lipopolysaccharide exposure on immune response modulation in the quail gut

Poultry Science 2026 Open access

Read full text
Authors: Juliana dos Santos Conceição, Angélica de Souza Khatlab, Eliane Gasparino, Thaís Pacheco Santana, Amanda Silva Carvalho, Marcus Vinícius de Aragão Batista, Marcelo Santana Filho, Simone Eliza Facioni Guimarães, Jodnes Sobreira Vieira, Ana Paula Del Vesco
DOI: 10.1016/j.psj.2026.106418
Cited by: 1
References: 176

Abstract

Embryogenesis is a critical programming window in birds, during which environmental factors can reshape gene expression and influence adaptive capacity after hatching. However, little is known about how embryonic thermal manipulation modulates intestinal immune and metabolic responses to inflammatory challenge later in life. This study evaluated the effects of embryonic thermal manipulation on the intestinal transcriptomic response of Japanese quail (Coturnix coturnix japonica) challenged with lipopolysaccharide (LPS). A 2 × 2 factorial design was applied, including two incubation temperatures (control - 37.5°C; high - 39°C) and two challenge conditions (LPS and saline solution). At 25 days post-hatch, jejunum samples were collected after inoculation and subjected to RNA-seq analysis. High incubation temperature significantly reduced (p

Fields of Study & Subjects

Animal Genetics and Reproduction Animal Nutrition and Physiology Aquaculture disease management and microbiota

Publication details

Journal / source
Poultry Science
Publisher
Elsevier BV
Volume
105
Issue
4
Pages
106418–106418
Publication date
13 January 2026
Language
EN